Clomid - Clomiphene citrate
clomid
Clomid is not an anabolic/androgenic steroid. Since it is a synthetic
estrogen it belongs, however, to the group of sex hormones. In school
medicine Clomid is normally used to trigger ovulation. Clomid, by
setting in motion the process of releasing hormones, stimulates the
release of gonadotropin and triggers ovulation in women with
anovulatory cycles and who are sterile because of this. Although this
is actually a drug destined for women its effect on men is undisputed.
The manufacturer of Dyneric,the Merrell Dow Pharma GmbH, writes in its
package insert for the German version of Clomid: "Dyneric causes an
improved activity between mid-brain, pituitary gland, and ovaries."
What however is not mentioned is that Dyneric also improves the
activity between mid-brain (hypothalamus), pituitary gland
thypophysis), and testes in men. Clomid has a strong influence on the
hypothalamohypophysial testicular axis. It stimulates the hypophysis
to release more gonadotropin so that a faster and higher release of
FSH (follicle stimulating hormone) aud LH (luteinizing hormone)
occurs. This results in an elevated endogenous (body's own
testosterone level. Clomid is especially effective when the body's own
testosterone production, due to the intake of anabolic/androgenic
steroids, is suppressed. In most cases Clomid can normalize the
testosterone level and the spermatogenesis (sperm development)within
10-14 days. For this reason Clomid is primarily taken after steroids
are discontinued. At this time it is extremely important to bring the
testosterone production to a normal level as quickly as possible so
that the loss of strength and muscle mass is minimized. Even better
results can be achieved if Clomid is combined with HCG or when Clomid
is used after the intake of HCG. The difference between Clomid and HCG
lies in the fact that Clomid has a direct influence on the
hypothalamus and the hypophysis, thus regenerating the entire
regulating cycle while HCG imitates the effect of the luteinizing
hormone (LH) which stimulates the Ledig's cells fo produce more
testosterone. Since HCG, unlike Clomid, leads to a distinctly elevated
plasmatestosterone level within a few hours, many athlets first take
HCG and then Clomid (see also HCG).
Paradoxically, although Clomid is a synthetic estrogen it also works
as an antiestrogen. The reason is that Clomid has only a very low
estrogenic effect and thus the stronger estrogens which, for example
form during the aromatization of steroids, are blocked at the
receptors. These would include those that develop during the
aromatizing of steroids. This does not prevent the steroids from
aromatizing but the increased estrogen is mostly deactivated since it
cannot attach to the receptors. The inereased water retention and the
possible signs of feminization can thus be reduced or even completely
avoided. Since the antiestrogenic effect of Clomid is lower than those
found in Proviron, Nolvadex, and Teslac it is mainly taken as a
testosterone stimulant. From the German book Doping By Brigitte
Berendonk the reader can learn that Clomid is not only used in
bodybuilding: "During the 1980's Clomiphene (table 2) has been used, a
medication that promotes the production of the body's own stimulating
hormone, gonadotropin, which in turn increases the testosterone level.
- It is, for example, administered to women as a so-called
antiestrogen to trigger ovulation ("ovulation stimulator").Clomiphene
(usually the Hungarian compound Clostilbegyt) was used by rowers
(resp. Prof. Dr. Herbert Gurtler) and weightlifers (Dr Lathan; p. 187)
since the late 1970's. Increasingly, it was used in other sports
disciplines as well, including track and field athletics. Riedel, at
the time, happily made the handwritten entry in his notebook:
"Substance that is not an anabolic: generally traceable but is not a
doping substance." The dosages were horrendous. I found entries of up
to l5 times 100mg daily and the report that the positive effect lasts
up to 20 days after the last tablet is taken. And it was already
assured since 1982 that the increased testosterone production after
doping with Clomiphene did not reveal traits of the T/E quotient
(testosterone/epitestosterone quotient, the author)during doping
tests.
Side effects of Clomid are very rare if reasonable dosages are taken.
Possible side effects are climacteric hot flashes and occasional
visual disturbances which can manifest themselves in blurred vision,
giving flickering or flashing. Should visual distuibances occur, the
manufacturer recommends discontinuing Clomid treatment. Inadequate
liver functions cannot be excluded;however,they are very unlikely in
women enlargement of the ovaries and abdominal pain can occur since
Clomid stimulates the ovaries. When taking Clomid multiple pregnancies
are possible as well. As for the dosage, 50-100 mg/per day(1-2
tablets) seems to be sufficient. The tablets are usually taken with
fluids after meals. If several tablets are taken it is recomended that
they be administered in equal doses distributed throughout the day.
The duration of intake should not exceed 10 to 14 days. Most athlets
begin with 100 mg/day taking one 50mg tablet every morning and evening
after meals. After the fifth day the dosage is often reduced to only
one 50mg tablet per day. It is normally not necessary to take the
compound for more than 10 days in order to increase the endogenus
testosterone production. Since Clomid should not be taken for a
prolonged time its application as an antiestrogen must be excluded
because, for that purpose, it would have to be taken for several
weeks. Clomid is relatively expensive. A package with 10 tablets costs
approx. $35 - 45 on the black market. Fortunately, since the intake is
only for a brief time, the financial burden usually becomes
acceptable. The foreign compounds such as the Spanish Omifin are
considerably cheaper and cost less than $2 per tablet.
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by Bill Roberts - Clomid is the anti-estrogen of choice for
improving recovery of natural testosterone production after a
cycle, improving testosterone production of endurance athletes, and
is also effective in reducing risk of gynecomastia during a cycle
employing aromatizable steroids.
While it has been claimed that Clomid "stimulates" production of LH
and therefore of testosterone, in fact Clomids activity is achieved
not by stimulation of the hypothalamus and pituitary, but by
blocking their inhibition by estrogen.
Clomid is a mixed estrogen agonist/antagonist (activator/blocker)
which, when bound to the estrogen receptor, puts it in a somewhat
different conformation (shape) than does estradiol. The estrogen
receptor requires binding of an estrogen or drug at its binding
site and also the binding of any of several cofactors at different
sites. Without the binding of the cofactor, the estrogen receptor
is inactive. Different tissues use different cofactors. Some of
these cofactors are able to bind to the estrogen receptor/Clomid
complex, but others are blocked due to the change in shape. The
result is that in some tissues Clomid acts as an antagonist -- the
cofactor used in that tissue cannot bind and so the receptor
remains inactive -- and in others Clomid acts as an agonist
(activator), because the cofactors used in that tissue are able to
bind.
Clomid is an effective antagonist in the hypothalamus and in breast
tissue. It is an effective agonist in bone tissue, and for
improving blood cholesterol.
Clomid also has the property of reducing the adverse effect of
exercise-induced damage of muscle tissue. This is very significant
for endurance athletes but is not very significant, if at all
significant, with reasonable weight training. Clomid does not
perceptibly affect gains of the weight trainer either favorably or
adversely in my experience.
The drug seems to have estrogenic effects on mood, which can be
beneficial (improving relationships with women by improving
empathy) or can yield depression or PMS-like symptoms, but for most
users there is no significant effect either way.
The claim that duration of intake should not exceed 10-14 days is
incorrect. Clinical studies with male patients have been for
periods of a year or longer. This error probably originates from
the fact that, for use in women, due to the menstrual cycle there
would obviously be no point in trying to stimulate ovulation all
four weeks of the month. Thus, use in women is limited to 10-14
days. That limitation is not because of toxicity.
Clomid is in fact useful throughout a cycle if aromatizable drugs
are being used. I do think however that to be conservative, one
should use it no more than 2/3 of the time throughout the year or a
little less.
Product Information
Courtesy Pharma Group
Product Name: CLOMIFEN
International Name: Clomid
Contents: 25 mg
Delivery: 20 caps
Manufacturer: Casen
Pharmacy Price: $14.00
Active Substances: Clomiphene Citrate
